Employees overview – University of Copenhagen

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Novo Nordisk Foundation Center for Basic Metabolic Research > Employees

Jonas Thue Treebak

Jonas Thue Treebak

Associate Professor

Member of:

  • Novo Nordisk Foundation Center for Basic Metabolic Research

Primary fields of research

  • Skeletal muscle physiology with special emphasis on the mechanisms regulating glucose and fat metabolism.
  • Involvement of NAD salvage pathways for maintaining mitochondrial function and insulin sensitivity.
  • Signaling pathways in skeletal muscle responsible for increasing insulin sensitivity in response to metabolic stress.

Selected publications

  1. Published

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O., Nielsen, R., Albrechtsen, A. & Hansen, T. 2014 In : Nature. 512, 7513, p. 190-193 4 p.

    Publication: Research - peer-reviewLetter

  2. Published

    Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 in human skeletal muscle

    Treebak, J. T., Pehmøller, C., Kristensen, J. M., Kjøbsted, R., Birk, J. B., Schjerling, P., Richter, E., Goodyear, L. J. & Wojtaszewski, J. 2014 In : Journal of Physiology. 592, 2, p. 351-375 25 p.

    Publication: Research - peer-reviewJournal article

  3. Published

    AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

    Brandauer, J., Vienberg, S. G., Andersen, M. A., Jørgensen, S. R., Risis, S., Larsen, P., Kristensen, J. M., Frøsig, C., Leick, L., Fentz, J., Jørgensen, S. B., Kiens, B., Wojtaszewski, J., Richter, E., Zierath, J. R., Goodyear, L. J., Pilegaard, H. & Treebak, J. T. 2013 In : Journal of Physiology. 591, p. 5207-5220 14 p.

    Publication: Research - peer-reviewJournal article

  4. Published

    Impairments in site-specific AS160 phosphorylation and effects of exercise training

    Consitt, L. A., Van Meter, J., Newton, C. A., Collier, D. N., Dar, M. S., Wojtaszewski, J., Treebak, J. T., Tanner, C. J. & Houmard, J. A. 2013 In : Diabetes. 62, 10, p. 3437-3447 11 p.

    Publication: Research - peer-reviewJournal article

  5. Published

    Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo

    Lauritzen, H. P. M. M., Brandauer, J., Schjerling, P., Koh, H-J., Treebak, J. T., Hirshman, M. F., Galbo, H. & Goodyear, L. J. Sep 2013 In : Diabetes. 62, 9, p. 3081-92 12 p.

    Publication: Research - peer-reviewJournal article

  6. Published

    Acute exercise remodels promoter methylation in human skeletal muscle

    Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J. & Zierath, J. R. 7 Mar 2012 In : Cell Metabolism. 15, 3, p. 405-11 7 p.

    Publication: Research - peer-reviewJournal article

  7. Published

    GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

    Biensø, R. S., Jørgensen, S. R., Kiilerich, K., Aachmann-Andersen, N. J., Krogh-Madsen, R., Guerra, B., Plomgaard, P. S., van Hall, G., Treebak, J. T., Saltin, B., Lundby, C., Calbet, J. A. L., Pilegaard, H. & Wojtaszewski, J. 2012 In : Diabetes. 61, 5, p. 1090-1099 10 p.

    Publication: Research - peer-reviewJournal article

  8. Published

    Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

    Vendelbo, M., Clasen, B. F. F., Treebak, J. T., Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, T. S., Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, J., Møller, N. & Jessen, N. 2012 In : American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

    Publication: Research - peer-reviewJournal article

  9. Published

    Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

    Hunter, R. W., Treebak, J. T., Wojtaszewski, J. & Sakamoto, K. 2011 In : Diabetes. 60, 3, p. 766-774 9 p.

    Publication: Research - peer-reviewJournal article

  10. Published

    Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training

    Vind, B. F., Pehmøller, C., Treebak, J. T., Birk, J. B., Hey-Mogensen, M., Beck-Nielsen, H., Zierath, J. R., Wojtaszewski, J. & Højlund, K. 2011 In : Diabetologia. 54, 1, p. 157-167 11 p.

    Publication: Research - peer-reviewJournal article

  11. Published

    Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle

    Koh, H-J., Toyoda, T., Fujii, N., Jung, M. M., Rathod, A., Middelbeek, R. J-W., Lessard, S. J., Treebak, J. T., Tsuchihara, K., Esumi, H., Richter, E., Wojtaszewski, J., Hirshman, M. F. & Goodyear, L. J. 2010 In : Proceedings of the National Academy of Science of the United States of America. 107, 35, p. 15541-15546 6 p.

    Publication: Research - peer-reviewJournal article

  12. Published

    Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle

    Treebak, J. T., Taylor, E. B., Witczak, C. A., An, D., Toyoda, T., Koh, H-J., Xie, J., Feener, E. P., Wojtaszewski, J., Hirshman, M. F. & Goodyear, L. J. 2010 In : American Journal of Physiology: Cell Physiology. 298, 2, p. C377-C385 9 p.

    Publication: Research - peer-reviewJournal article

  13. Published

    A-769662 activates AMPK {beta}1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle

    Treebak, J. T., Birk, J. B., Hansen, B. F., Olsen, G. S. & Wojtaszewski, J. 2009 In : American Journal of Physiology: Cell Physiology. 297, 4, p. C1041-C1052 12 p.

    Publication: Research - peer-reviewJournal article

  14. Published

    Genetic impairment of AMPK{alpha}2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice

    Maarbjerg, S. J., Jørgensen, S. B., Rose, A. J., Jeppesen, J., Jensen, T. E., Treebak, J. T., Birk, J. B., Schjerling, P., Wojtaszewski, J. & Richter, E. 2009 In : American Journal of Physiology: Endocrinology and Metabolism. 297, 4, p. E924-E934 11 p.

    Publication: Research - peer-reviewJournal article

  15. Published

    Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmøller, C., Treebak, J. T., Birk, J. B., Chen, S., Mackintosh, C., Hardie, D. G., Richter, E. & Wojtaszewski, J. 2009 In : American Journal of Physiology: Endocrinology and Metabolism. 297, 3, p. E665-E675 11 p.

    Publication: Research - peer-reviewJournal article

  16. Published

    Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frøsig, C., Pehmøller, C., Chen, S., Maarbjerg, S. J., Brandt, N., Mackintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E., Pilegaard, H. & Wojtaszewski, J. 2009 In : Diabetologia. 52, 5, p. 891-900 10 p.

    Publication: Research - peer-reviewJournal article

  17. Published

    Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle

    Glund, S., Treebak, J. T., Long, Y. C., Barres, R., Viollet, B., Wojtaszewski, J. & Zierath, J. R. 2009 In : Endocrinology. 150, 2, p. 600-606 7 p.

    Publication: Research - peer-reviewJournal article

  18. Published

    Role of 5'AMP-activated protein kinase in skeletal muscle

    Treebak, J. T. & Wojtaszewski, J. F. P. 2008 In : International Journal of Obesity. 32 Suppl. 4, p. S13-S17 5 p.

    Publication: ResearchReview

  19. Published

    Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling

    Deshmukh, A. S., Treebak, J. T., Long, Y. C., Viollet, B., Wojtaszewski, J. F. P. & Zierath, J. R. 2008 In : Molecular Endocrinology. 22, 5, p. 1105-12 8 p.

    Publication: Research - peer-reviewJournal article

  20. Published

    Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment

    Højlund, K., Glintborg, D., Andersen, N. R., Birk, J. B., Treebak, J. T., Frøsig, C., Beck-Nielsen, H. & Wojtaszewski, J. F. P. 2008 In : Diabetes. 57, 2, p. 357-366 10 p.

    Publication: Research - peer-reviewJournal article

  21. Published
  22. Published

    AS160 phosphorylation is associated with activation of alpha2beta2gamma1 - but not alpha2beta2gamma3 -AMPK trimeric complex in skeletal muscle during exercise in humans

    Treebak, J. T., Birk, J. B., Rose, A. J., Kiens, B., Richter, E. & Wojtaszewski, J. 2007 In : American Journal of Physiology: Endocrinology and Metabolism. 292, 3, p. E715-E722 8 p.

    Publication: Research - peer-reviewJournal article

  23. Published

    Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

    Jørgensen, S. B., Treebak, J. T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J. & Richter, E. 2007 In : American Journal of Physiology: Endocrinology and Metabolism. 292, 1, p. E331-E339 9 p.

    Publication: Research - peer-reviewJournal article

  24. Published

    AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits

    Treebak, J. T., Glund, S., Deshmukh, A., Klein, D. K., Long, Y. C., Jensen, T. E., Jørgensen, S. B., Viollet, B., Andersson, L., Neumann, D., Wallimann, T., Richter, E., Chibalin, A. V., Zierath, J. R. & Wojtaszewski, J. 2006 In : Diabetes. 55, 7, p. 2051-2058 8 p.

    Publication: Research - peer-reviewJournal article

ID: 7974