Target - The impact of our genomes on individual – University of Copenhagen

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Novo Nordisk Foundation Center for Basic Metabolic Research > Research > Research Project Websites > Target

TARGET

Contact

 

Professor Torben Hansen
The Novo Nordisk Foundation Center for Basic Metabolic Research
Section of Metabolic Genetics
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 1-3
2200 Copenhagen N
Denmark
Phone: +45 35337129
Email: torben.hansen@sund.ku.dk

Associate Professor Jens-Christian Holm
Chief physician, Research Director & Head of The Children’s Obesity Clinic
Department of Pediatrics
Copenhagen University Hospital Holbaek
Smedelundsgade 60
4300 Holbaek
Denmark
Phone +45 59484208
Fax +45 59484209
Mobile +45 26207533
Email: jhom@regionsjaelland.dk

 

Management

 

Torben Hansen
Professor, Appointed Scientific Director
The Novo Nordisk Foundation Center for Basic Metabolic Research
Section of Metabolic Genetics
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 1-3
2200 Copenhagen N
Denmark
Phone: +45 35337129
Email: torben.hansen@sund.ku.dk

Oluf Borbye Pedersen
Professor, The Novo Nordisk Foundation Center for Basic Metabolic Research
Section of Metabolic Genetics
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 1-3
2200 Copenhagen N
Denmark
Phone: +45 35337121
Email: oluf@sund.ku.dk 

Jens-Christian Holm
Chief physician, Clinical Associate Professor
Research Director & Head of The Children’s Obesity Clinic
Department of Pediatrics

Copenhagen University Hospital Holbaek
Smedelundsgade 60
4300 Holbaek
Denmark
Phone +45 59484208
Fax +45 59484209
Mobile +45 26207533
Email: jhom@regionsjaelland.dk

Thue W. Schwartz

Professor, Scientific Director
The Novo Nordisk Foundation Center for Basic Metabolic Research
Section of Metabolic Receptology and Enteroendocrinology

Faculty of Health and MedicalSciences
University of Copenhagen
Blegdamsvej 3B

2200 Copenhagen N
Denmark
Phone: +45 35327603
Email: tws@sund.ku.dk

Press

 

Bevillinger fra Det Strategiske Forskningsråd, Programkomiteen for individ, sygdom og samfund, november 2011

Professor Torben Hansen receives DKK 19.6 million from The Danish Agency for Science, Technology and Innovation

Forskningsstøtte blåstempler nye vinkler på svær overvægt

Research

 

 

The research within TARGET will at the genome and gut microbiome levels identify subsets of obese children who carry a specific human genetic variation and/or gut microbiome profile. Furthermore, genome and gut microbiome dependent responses to prevention and therapy will be identified. Thus, the outlined research program is to be considered as an essential step to stem the tide of the global increase in childhood obesity and the related co-morbidities.

Specifically we will:

  • Identify novel monogenic forms of childhood obesity using whole exome sequencing (WES) of accessible coding regions of the human genome in families with obesity segregating as an autosomal dominant trait
  • Identify subsets of children with monogenic forms of obesity which respond to or are resistant to a tailored one-year intensive weight loss intervention
  • Identify gut microbiome profiles which associate with specific forms of childhood obesity
  • Identify subsets of children with a specific gut microbiome profile which respond to or are resistant to a one-year intensive weight loss intervention

We will meet these aims by first of all recruiting and characterizing families with childhood obesity segregating as an autosomal dominant trait. We will then identify novel monogenic forms of childhood obesity using WES of accessible coding regions of the human genome. A WES study will be performed in 10 families with childhood obesity segregating as an autosomal dominant trait and in additional 20 obese children; 10 of whom respond and 10 of whom are resistant to tailored weight loss intervention. We will then undertake functional in vitro studies of putative disease causing gene variants.

Furthermore, we will perform baseline phenotypic characterization of obese- and control children for gut microbiome profiling. After the completion of a one-year structured weight loss intervention, we will in the obese children identify gut microbiome profiles which respond or are resistant to weight loss intervention. Profiling of the gut microbiome will be carried out by metagenomic sequencing of stool samples from 200 obese children and 100 control children collected at baseline. Following taxonomic analysis, we will then define microbiome profiles which associate with or are resistant to a one-year structured weight loss intervention.

The aims and workflow are summarized in the figure below:

 

Research alliances

Section for Metabolic Genetics

The Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 1-3
2200 Copenhagen N
Denmark
Web

Section for Metabolic Receptology

The Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen
Blegdamsvej 3b
2200 Copenhagen N
Denmark
Web

The Children’s Obesity Clinic

Department of Pediatrics
Copenhagen University Hospital Holbaek
Smedelundsgade 60
4300 Holbæk
Denmark
Web

Department of Diagnostic Radiology

Copenhagen University Hospital Herlev
Herlev Ringvej 75
2730 Herlev
Denmark
Web

The French National Institute for Agricultural Research (INRA), France

147 rue de l'université
75338 Paris Cedex 07
France
Web

Beijing Genomics Institute (BGI)

Beishan industry zone,Yantian dist. Shenzhen,
GuangDong 518083
China
Web

Staff

University of Copenhagen

Professor Oluf Borbye Pedersen
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  borbye@sund.ku.dk

Professor, Appointed Scientific Director Torben Hansen
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  torben.hansen@sund.ku.dk

Professor, Scientific Director Thue W. Schwartz
Section for Metabolic Receptology and Enteroendocrinology
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail: tws@sund.ku.dk

Associate professor Manimozhiyan Arumugam ,
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail: 
arumugam@sund.ku.dk

Postdoc Christian Theil Have,
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail: c.have@sund.ku.dk

Postdoc Albert Palleja,
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail: palleja@sund.ku.dk

Postdoc Annette Marianne Prior Gjesing
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  anette.gjesing@sund.ku.dk

PhD fellow Mette Hollensted
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  mette.hollensted@sund.ku.dk

PhD fellow Theresia Maria Schnurr
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  tmschnurr@sund.ku.dk

PhD fellow Vincent Rosenbaum Appel
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail:  vincent@sund.ku.dk

Data manager Peter Sandbeck
Section for Metabolic Genetics
The Novo Nordisk Foundation Center for Basic Metabolic Research
E-mail: psandbeck@sund.ku.dk 

 

The Children’s Obesity Clinic