Section for Metabolic Imaging and Liver Metabolism – University of Copenhagen

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Novo Nordisk Foundation Center for Basic Metabolic Research > Metabolic Imaging and ...

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

Research output: Research - peer-reviewJournal article

Rachel J Perry, Liang Peng, Natasha A Barry, Gary W Cline, Dongyan Zhang, Rebecca L Cardone, Kitt Falk Petersen, Richard G Kibbey, Andrew L Goodman, Gerald I. Shulman

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

Original languageEnglish
JournalNature
Volume534
Issue number7606
Pages (from-to)213-7
Number of pages5
ISSN0028-0836
DOIs
StatePublished - 9 Jun 2016

    Research areas

  • Acetates, Animals, Brain, Diet, High-Fat, Gastrointestinal Microbiome, Ghrelin, Glucose, Hyperphagia, Insulin, Insulin-Secreting Cells, Metabolic Syndrome X, Obesity, Parasympathetic Nervous System, Rats, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

ID: 166693158