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Minisymposium_PDZ domain proteins

PDZ (PSD-95/Discs-large/ZO-1 homology) domains are among the most common protein recognition domains with estimated over 270 domains encoded by the human genome. They mediate cellular protein-protein interactions and serve important roles in receptor targeting and in the assembly of receptor protein signaling complexes.

Recent efforts have unraveled many new physiological and pathophysiological functions of PDZ domain proteins, and there is increasing evidence that targeting PDZ domain proteins is beneficial in cancer stroke, addiction and neuropathic pain.
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